Hydroxyurea inhibition of DNA synthesis in ascites tumor.
نویسندگان
چکیده
منابع مشابه
Inhibition of DNA synthesis in HeLa cells by hydroxyurea.
The introduction of hydroxyurea as a potentially useful agent in leukemia chemotherapy (e.g., Ref. 21) has led to several studies of its effects at the cellular level. Mohler (8) found that this drug both inhibits division and causes death of Chinese hamster cells and that it inhibits division of HeLa S3 cells as well. Young and Hodas (24) reported that synthesis of DNA in HeLa cells is inhibit...
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The following comix>unds inhibited incorporation of thymidine-3H into the DNA of HeLa cells without significantly impairing cellular incorjwration of uridine-3H into RNA or loucine-3H into protein; the}' are listed in order of potency. Dihydro.xyurea > jV-methylhydroxyurea > .V-acetylhydroxyurea = hydroxyurea = A'-hydroxyguanidine = N-hydroxyurethane = AT-ethylhydroxyurea > 3-phenyl-l-hydroxyur...
متن کاملRibonucleotide reductase and DNA synthesis in Ehrlich ascites tumor cells.
The levels of ribonucleotide reductase, DNA polymerase, thymidine kinase, and labeled thymidine incorporation into DNA were measured in Ehrlich ascites tumor cells as a function of time after inoculation of the tumor in mice. The levels of ribonucleotide reductase and thymidine kinase activities decreased with tumor growth, while the level of DNA polymerase activity did not decrease. Thymidine ...
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As part of experimental studies on the synchronisation of mammalian cell populations in vivo, the uroliferative resuonse of rat embrvo cells (18th dav bf gestation) was investigated follo&ng transpIacenta1 administration of hydroxyurea (HU). DNA synthesis was strongly inhibited by i.p. injection of a single dose of 0.25 or 0.5 mg HU/g body weight, for periods of 2.5 and 4.5 h, respectively. Rev...
متن کاملInhibition of DNA and RNA Synthesis by Daunorubicin in Sensitive and Resistant Ehrlich Ascites Tumor Cells in Vitro1
The effect of daunorubicin (DNR) on nucleic acid synthesis was investigated in vitro in cells from an Ehrlich ascites tumor that was sensitive in vivo to DNR and in cells from a subline of the tumor in which resistance to DNR had been developed in vivo. DNR inhibited DNA and RNA synthesis in sensitive as well as in resistant cells, as determined from the incorporation of three different radioac...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1965
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.53.5.1033